Endocrine Abstracts

Background: This study was conducted to determine whether prolactin (PRL) influences radiological findings of benign breast lesions.Patients and methods: We observed 50 patients with nipple discharge: 23 patients with normal serum prolactin levels (group 1; n=23) and 27 patients with hyperprolactinemia (group 2a; n=27). Patients observed during this study underwent breast ultrasonography (US) and mammography. Patients with hyperprolactinemi...

Background and aims: Many obese patients with type 2 diabetes mellitus (T2DM) are not adequatly controlled with oral antidiabetic therapy (OAD), even with combination between metformin and sulfonylurea (SU). When OADs no longer maintain good glycaemic control in obese T2DM, it is necessary to add insulin therapy. The aim of this study is to compare the effect of adding premixed insulin aspart 30(BIAsp30) vs. premixed human insulin 30/70 (BHI30) to support metformin therapy in ...

Background and aims: Metformin is the drug of first choice in obese patients with type 2 diabetes (T2DM), but in some patients it is not possible to achieve good glycaemic control by using metformin only. Starting from a fact that T2DM is a heterogeneous disorder due to the interaction of impaired early insulin secretion and peripheral insulin resistance, the aim of the present study was to evaluate and compare the efficacy of repaglinide vs. glimepirid on glycaemic control of...

Background: The aim of this study was to compare the influence of medicamentous and physiological hyperprolactinemia on bone turnover in female rats.Methods: Experimental animals (18 weeks old, Wistar female rats) were divided in the following groups: Group I: 9 rats, three week pregnant; Group II: ten female rats that were i.m. administrated Sulpirid (10 mg/kg) twice daily for three weeks; Group III: ten female rats that were i.m. administrated Sulpirid...